In October 2015, the Center for Agricultural and Rural Development at Iowa State University, Ames, Iowa hosted a two-day National Science Foundation-funded workshop exploring the challenges and pitfalls associated with integrating biophysical and economic models. The workshop brought together leading economists, statisticians, crop scientists, hydrologists, climate scientists, and other biophysical modelers, to identify and address the key scientific, engineering, and data challenges associated with understanding our food, energy, and water (FEW) system. Approximately 80 people attended the workshop with about half of them representing social scientists (primarily economists) and the rest from the physical and natural sciences. Economics and social sciences were intentionally emphasized so that the findings would be particularly relevant to research needs in those fields.