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Animal Industry Report

Extension Number

ASL R2276

Topic

Beef

Summary and Implications

Recognition of pathogen associated molecular patterns by Toll-like receptors (TLR) increases 1α-hydroxylase expression in bovine macrophages. This results in increased conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1,25- dihydroxyvitamin D3 (1,25(OH)2D3) in bovine macrophages. Production of 1,25(OH)2D3 in bovine macrophages indicates that 1,25(OH)2D3 may be involved in modulating the bovine immune response.

Copyright Holder

Iowa State University

Language

en

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