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Animal Industry Report

Extension Number

ASL R2384

Topic

Animal Health

Summary and Implications

A major hurdle to swine influenza vaccination of young piglets is maternal antibody interference. This interference is transient as it disappears when pigs reach about 3 months of age. We vaccinated piglets without and with interfering maternal antibody using a recombinant vector vaccine. In the absence of interfering maternal antibody, the vaccine was effective in inducing a strong immune response and greatly reduced the amount of virus. However, this same recombinant vaccine was not effective when interfering maternal antibodies were present. We are currently trying a higher dose of vaccine and different genes from SIV in hopes we can overcome this maternal antibody. Preliminary data from these new studies are promising.

Copyright Holder

Iowa State University

Language

en

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