Summary and Implications
A major hurdle to swine influenza vaccination of young piglets is maternal antibody interference. This interference is transient as it disappears when pigs reach about 3 months of age. We vaccinated piglets without and with interfering maternal antibody using a recombinant vector vaccine. In the absence of interfering maternal antibody, the vaccine was effective in inducing a strong immune response and greatly reduced the amount of virus. However, this same recombinant vaccine was not effective when interfering maternal antibodies were present. We are currently trying a higher dose of vaccine and different genes from SIV in hopes we can overcome this maternal antibody. Preliminary data from these new studies are promising.
Iowa State University
Bosworth, Brad T.; Erdman, Matthew M.; Irwin, Christa; Loynachan, Alan T.; and Harris, D.L. Hank
"Evaluation of a Virus-like Replicon Particle Vaccine Expressing
Proteins of Swine Influenza Virus in Pigs With and Without
Maternally Derived Antibodies ,"
Animal Industry Report:
AS 655, ASL R2384.
Available at: http://lib.dr.iastate.edu/ans_air/vol655/iss1/7