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Animal Industry Report

Extension Number

ASL R2488

Topic

Animal Health

Summary and Implications

Bovine mammary epithelial cells that were treated with bacterial lipopolysaccharide and 1,25-dihydroxyvitamin D3 showed an increase in the expression of the genes for inducible nitric oxide synthase (iNOS) and S100 calcium binding protein A12 (S100 A12). iNOS and S100 A12 are part of the innate immune response and expressed in the mammary gland during mastitis. Production of 1,25- dihydroxyvitamin D3 in the mammary gland during mastitis, then, may be an important component of the innate immune response.

Copyright Holder

Iowa State University

Language

en

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