Summary and Implications
We provide evidence that T-cell responses to Mycobacteria bovis are suppressed by the production of 1,25-dihydroxyvitamin D3 in monocytes and B-cells from cattle. Current vitamin D requirements for cattle are solely based on the classical endocrine mechanism of vitamin D signaling that regulates calcium homeostasis and should be re-evaluated to account for vitamin D signaling mechanisms in the immune system.
Iowa State University
Nelson, Corwin D.; Beitz, Donald C.; Reinhardt, Timothy A.; and Lippolis, John D.
"Regulation of Immune Responses to Mycobacteria bovis by a
Paracrine Mechanism of Vitamin D Signaling in Cattle,"
Animal Industry Report:
AS 657, ASL R2601.
Available at: http://lib.dr.iastate.edu/ans_air/vol657/iss1/25