Summary and Implications
Vaccination of swine with an alphavirus-derived replicon particle vaccine stimulates a non-specific immune response. This effect was seen when animals were challenged with PRRSV at 24 hours post-vaccination. Animals that received vaccine had reduced viremia as measured by quantitative RT-PCR when compared to placebo. These results highlight the potential of replicon particle vaccines to induce robust immune responses in swine.
Iowa State University
Mogler, Mark; Vander Veen, Ryan Lee; Kamrud, Kurt I.; and Harris, D.L. Hank
"Replicon Particle Administration Prior to Challenge Reduces
Animal Industry Report:
AS 658, ASL R2674.
Available at: http://lib.dr.iastate.edu/ans_air/vol658/iss1/6