Summary and Implications
The objective of this study was to determine the effect of maternal long chain n-3 fatty acid supplementation on the DNA methylation profile of offspring buffy coats. We demonstrated several methylated regions across the genome were influenced by maternal n-3 dietary treatment. Therefore, feeding n-3 fatty acids to sows during gestation and lactation may result in a DNA methylation imprint on offspring buffy coats that persists beyond the nursery phase and may alter the phenotype of the growing pig.
Iowa State University
Boddicker, Rebecca; Koltes, James; Fritz, Eric; Mani, Venkatesh; Reecy, James M.; Baumgard, Lance H.; Gabler, Nicholas K.; and Ross, Jason W.
"Prenatal and Postnatal Dietary n-3 Fatty Acid Supplementation Alters Buffy Coat DNA Methylation Profile in Pigs ,"
Animal Industry Report:
AS 658, ASL R2741.
Available at: http://lib.dr.iastate.edu/ans_air/vol658/iss1/73