Summary and Implications
Genomic regions tend to be inherited in blocks known as haplotypes. The general region spanning PLAG1 shows association with various traits in beef cattle. There are few haplotypes spanning PLAG1, and these are common across breeds but do not capture the true effect. Higher density 770K genotyping demonstrates greater diversity of haplotypes in this region. The tag SNP in Holstein and Jersey dairy cattle segregates in Hereford cattle who show no effect in this region. Collectively, these results show the 50K SNP chip has inadequate coverage in this region of the genome.
Iowa State University
Yan, Jingjing; Saatchi, Mahdi; Su, Hailin; Lee, Jungjae; Fernando, Rohan L.; and Garrick, Dorian J.
"Characterization and Associations of Haplotypes Containing PLAG1 in Cattle,"
Animal Industry Report:
AS 660, ASL R2851.
Available at: http://lib.dr.iastate.edu/ans_air/vol660/iss1/16