Campus Units

Biochemistry, Biophysics and Molecular Biology

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2012

Journal or Book Title

MedChemComm

Volume

3

Issue

8

First Page

899

Last Page

904

DOI

10.1039/C2MD20030A

Abstract

The actinomycetes family of bacteria is classically considered a rich source of natural products [1]. It is often suggested that such compounds have been selected by evolution to have biological activity [2]. For example, given the microbial-rich soil environment of the actinomycetes native habitat, their natural products have been suggested to serve in chemical warfare and/or signaling, which has been further connected to their leading role in providing pharmaceutically relevant antibiotic agents [3]. Nevertheless, surprisingly few of these molecules have been definitively assigned specific physiological roles in the native producing bacteria.

Comments

This is a manuscript of an article published as Mann, F.M., Peters, R.J. (2012) “Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis”, Med. Chem. Commun., 3(8):899-904, doi: 10.1039/C2MD20030A. Posted with permission.

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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