Campus Units

Biochemistry, Biophysics and Molecular Biology

Document Type

Article

Publication Version

Published Version

Publication Date

2009

Journal or Book Title

Journal of the American Chemical Society

Volume

131

Issue

48

First Page

17526

Last Page

17527

DOI

10.1021/ja9019287

Abstract

Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.

Comments

This article is published as Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis, Francis M. Mann, Meimei Xu, Xiaoming Chen, D. Bruce Fulton, David G. Russell, and Reuben J. Peters, Journal of the American Chemical Society 2009 131 (48), 17526-17527,DOI: 10.1021/ja9019287. This article is made available via ACS AuthorChoice.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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