A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

Thumbnail Image
Date
2009-01-01
Authors
Gao, Wei
Hillwig, Matthew
Huang, Luqi
Cui, Guanghong
Wang, Xueyong
Kong, Jianqiang
Yang, Bin
Peters, Reuben
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Peters, Reuben
Distinguished Professor
Research Projects
Organizational Units
Journal Issue
Is Version Of
Versions
Series
Department
Biochemistry, Biophysics and Molecular Biology
Abstract

Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.

Comments

This article is published as A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights, Wei Gao, Matthew L. Hillwig, Luqi Huang, Guanghong Cui, Xueyong Wang, Jianqiang Kong, Bin Yang, and Reuben J. Peters, Organic Letters 2009 11 (22), 5170-5173, DOI: 10.1021/ol902051v. This article is made available via ACS AuthorChoice.

Description
Keywords
Citation
DOI
Copyright
Thu Jan 01 00:00:00 UTC 2009
Collections