Campus Units

Biochemistry, Biophysics and Molecular Biology

Document Type

Article

Publication Version

Published Version

Publication Date

2009

Journal or Book Title

Organic Letters

Volume

11

Issue

22

First Page

5170

Last Page

5173

DOI

10.1021/ol902051v

Abstract

Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.

Comments

This article is published as A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights, Wei Gao, Matthew L. Hillwig, Luqi Huang, Guanghong Cui, Xueyong Wang, Jianqiang Kong, Bin Yang, and Reuben J. Peters, Organic Letters 2009 11 (22), 5170-5173, DOI: 10.1021/ol902051v. This article is made available via ACS AuthorChoice.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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