Campus Units

Biochemistry, Biophysics and Molecular Biology, Zoology

Document Type

Article

Publication Version

Published Version

Publication Date

1985

Journal or Book Title

Molecular and Cellular Biology

Volume

5

Issue

11

First Page

3289

Last Page

3292

DOI

10.1128/MCB.5.11.3289

Abstract

Mitogen-regulated protein (MRP) is secreted by certain immortal murine cell lines (Swiss 3T3, BNL) stimulated with serum or particular growth factors. We have identified a cDNA clone that encodes part of the protein and have confirmed that MRP is closely related to, if not identical to, the prolactin-related protein designated proliferin. MRP is not produced by primary mouse embryo fibroblasts to nearly the same extent as it is produced by many immortal or transformed lines. Control of expression of this protein by growth factors is achieved both by regulating the extent of transcription and by regulating the processing of the protein.

Comments

This is an article from Molecular and Cellular Biology 5 (1985): 3289, doi:10.1128/MCB.5.11.3289. Posted with permission.

Copyright Owner

American Society for Microbiology

Language

en

File Format

application/pdf

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