Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
Date
2008-01-01
Authors
Kraus, George
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed
Banerjee, Jayeeta
Parvin, Bahram
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Nilsen-Hamilton, Marit
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Biochemistry, Biophysics and Molecular BiologyChemistry
Abstract
A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.
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This is an article from Molecules 13 (2008): 986, doi:10.3390/molecules13040986. Posted with permission.
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Tue Jan 01 00:00:00 UTC 2008