Campus Units

Biochemistry, Biophysics and Molecular Biology, Mechanical Engineering

Document Type

Article

Publication Version

Published Version

Publication Date

2008

Journal or Book Title

Applied Physics Letters

Volume

93

First Page

143107

DOI

10.1063/1.2996411

Abstract

We report a sensor consisting of two micromachined cantilevers (a sensing/reference pair) that is suitable for detection of chemical and biological species. The sensing strategy involves coating the sensing cantilever with receptors that have high affinities for the analyte. The presence of analyte is detected by determining the differential surface stress associated with its adsorption/absorption to the sensing cantilever. An interferometric technique is utilized to measure the differential bending of the sensing cantilever with respect to reference. Surface stress associated with hybridization of single stranded DNA is measured to demonstrate the unique advantages of the sensor.

Comments

This is an article from Applied Physics Letters 93 (2008): 143107, doi:10.1063/1.2996411. Posted with permission.

Copyright Owner

American Institute of Physics

Language

en

File Format

application/pdf

Share

COinS