Campus Units

Biochemistry, Biophysics and Molecular Biology, Veterinary Pathology

Document Type

Article

Publication Version

Published Version

Publication Date

2010

Journal or Book Title

International Journal of Oncology

Volume

37

Issue

5

First Page

1195

Last Page

1202

DOI

10.3892/ijo_00000771

Abstract

Pregnancy is a well established protective factor against breast cancer. One explanation for protection is the increased differentiation status of the parous epithelium. However, this does not explain the association of parity with increased aggressiveness of breast cancers, particularly cancers that occur soon after pregnancy. Because tumor aggressiveness can be influenced by the cell population that surrounds the mammary epithelium, we examined the potential role of the immune system in establishing a long-term difference between the mammary glands of primiparous and virgin animals. Specific mRNA levels, enzyme activities and antigen expressing cells were quantified in primiparous and virgin mammary glands from Sprague-Dawley rats in diestrous. Our results show that macrophages, but not neutrophils or B-cells, are specifically increased in fully involuted glands compared with age-matched virgin mammary glands. Macrophages play a dual role in tumor progression, both opposing and supporting the process. Our finding of an increased macrophage population in the primiparous mammary gland could explain the dichotomy of the reported association of parity with decreased breast cancer incidence and increased breast cancer aggressiveness.

Comments

This is an article from International Journal of Oncology 37 (2010): 1195, doi:10.3892/ijo_00000771. Posted with permission.

Copyright Owner

Spandidos Publications

Language

en

File Format

application/pdf

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