Document Type

Article

Publication Date

2014

Journal or Book Title

Journal of Natural Products

Volume

77

Issue

9

First Page

2144

Last Page

2147

DOI

10.1021/np500422d

Abstract

While more commonly associated with plants than microbes, diterpenoid natural products have been reported to have profound effects in marine microbe–microbe interactions. Intriguingly, the genome of the marine bacterium Salinispora arenicola CNS-205 contains a putative diterpenoid biosynthetic operon, terp1. Here recombinant expression studies are reported, indicating that this three-gene operon leads to the production of isopimara-8,15-dien-19-ol (4). Although 4 is not observed in pure cultures of S. arenicola, it is plausible that the terp1 operon is only expressed under certain physiologically relevant conditions such as in the presence of other marine organisms.

Comments

Reprinted (adapted) with permission from Journal of Natural Products 77 (2014): 2144, doi:10.1021/np500422d. Copyright 2014 American Chemical Society.

Rights

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Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf