Document Type

Article

Publication Date

7-2012

Journal or Book Title

Journal of the American Chemical Society

Volume

134

Issue

28

First Page

11369

Last Page

11371

DOI

10.1021/ja3043245

Abstract

Mechanistic proposals for the carbocation cascade reaction leading to the tricyclic sesquiterpene pentalenene are assessed in light of the results of isotopically sensitive branching experiments with the H309A mutant of pentalenene synthase. These experimental results support a mechanism for pentalenene formation involving a 7-protoilludyl cation whose intermediacy was first predicted using quantum-chemical calculations.

Comments

Reprinted with permission from Journal of the American Chemical Society 134 (2012): 11369, doi:10.1021/ja3043245. Copyright 2012 American Chemical Society.

Rights

One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions). For any other uses, please submit a new request.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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