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Theses/Dissertations from 2016

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Structure and function of the Plasmodium falciparum apicoplast DNA polymerase: the first look at an "atypical" A-family polymerase and its potential in antimalarial drug discovery, Morgan Eilise Milton

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Exploring genetic-based metabolic and morphological diversity of Arabidopsis thaliana ecotypes influenced by the environment, Jennifer R. Robinson

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Functional characterization of dASCIZ in gene expression and development in Drosophila melanogaster, Saheli Sengupta

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Amylolysis of eight different starches with four different species of alpha-amylase, Robert Leonard Sheets

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Electron transfer and redox chemistry in hexa-coordinate hemoglobins, Navjot Singh

Theses/Dissertations from 2015

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Structural mechanisms of bacterial multidrug efflux pumps, their regulation, and implications for future research in silico, Sylvia Vu Do

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Self-assembly of biomineralization protein Mms6 and its function as a ferric iron reductase that associates with lipid membranes, Shuren Feng

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Functional analysis of the propanediol utilization microcompartment shell proteins PduB and PduB' in Salmonella enterica, Brent Lehman

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Regulation of gene expression and chromatin structure by JIL-1 mediated histone H3 serine10 phosphorylation in Drosophila, Yeran Li

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Mechanistic insights into the regulation of neuronal SNAREs mediate membrane fusion: interplay between core fusion machinery and regulatory proteins, Xiaochu Lou

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Investigating the roles of diterpenoids in rice-Xanthomonas oryzae interactions, Xuan Lu

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Investigating the role of chromatin structure in modulating SAGA mediated nucleosomal acetylation, Chitvan Mittal

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Local vs. systemic modifications of soybean (Glycine max) defense signals in response to soybean aphid (Aphis glycines Matsumura) infestation, Khoi Nguyen

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Understanding the BASEs for catalysis in class II diterpene cyclases results in novel product chemistries, Kevin Charles Potter

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Fermentative production of short-chain fatty acids and methyl ketones in Escherichia coli, Alexandra Rachel Volker

Theses/Dissertations from 2014

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Isolation and binding properties of methanobactin from the facultative methanotroph Methylocystis strain SB2, Nathan Bandow

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Characterization of Ebola virus VP35 first basic patch as a therapeutic target, Jennifer Binning

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New insights into the functional organization of xyloglucan biosynthetic enzymes and their catalytic mechanism, Yi-Hsiang Chou

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Enzymatic components and physiological roles of mitochondrial fatty acid biosynthesis in plants, Xin Guan

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The role of the Immunoglobulin G1 Fc N-glycan in FcγRIIIa affinity, Quinlin Hanson

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Role of the PduL enzyme in the function of primitive bacterial organelles found in Salmonella, Yu Liu

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Aptamer sensors for live-cell imaging of Pol II promoter activity, Judhajeet Ray

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Characterization of RNase X25 and Lamp1 in Drosophila melanogaster, Ayesha Riaz

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Investigation of SNARE-mediated exocytosis controlled by synaptic regulatory proteins, Jaeil Shin

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Metabolomics based gene function annotation in Escherichia coli and Methanosarcina acetivorans with genetic gain- or loss-of-function strains, Lucas John Showman

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A single molecular study of the regulation of SNARE-mediated membrane fusion, Jaekyun Song

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Biochemical characterization of the biotin-dependent carboxylases, acetyl-CoA carboxylase and 3-methylcrotonyl-CoA carboxylase, Bryon A. Upton

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Epigenetic interplay between histone H3K9me2 and JIL-1 mediated histone H3S10ph, Chao Wang

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Function of class one nonsymbiotic plant hemoglobins, Xiaoguang Wang

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Fidelity, mismatch extension, and proofreading measurements of apPOL, the Plasmodium falciparum apicoplast-targeted DNA polymerase, Bentley Wingert

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Mechanistic insight into the regulation of Tec family kinase activity - substrate selection and conformational preferences, Qian Xie

Theses/Dissertations from 2013

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Molecular regulation of IL-2 inducible T-cell kinase (Itk) and the Tec kinases: A combined experimental and computational study, with emphasis on the N-terminal Pleckstrin Homology domain, Scott Edward Boyken

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Optimization of methods for culturing Mycobacterium avium subsp. paratuberculosis from bovine milk and colostrum and application to samples collected from naturally infected dairy cows, Laura Kaitlan Bradner

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Wax ester biosynthetic pathway, Daolin Cheng

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Allosteric regulation of mammalian fructose-1,6-bisphosphatase, Yang Gao

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Characterization of the Arabidopsis thaliana acetyl-CoA synthetase putative carboxylate binding pocket, Jason H. Hart

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Characterization of acyl-ACP thioesterases for the purpose of diversifying fatty acid synthesis pathway, Fuyuan Jing

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Building and simulating protein machines, Ataur Rahim Katebi

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Step-specific investigation of SNARE-mediated membrane fusion, Sunae Kim

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Investigation of the process of SNARE mediated synaptic vesicle exocytosis, Ying Lai

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Investigating the evolution of cytochromes P450 involved in GA biosynthesis, Sibongile Mafu

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Characterization of the putative catalytic domain of two xyloglucan xylosyltransferases (XXTs) involved in the biosynthesis of xyloglucan in Arabidopsis thaliana, Rachel Ann Morris

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Fidelity of Plasmodium falciparum apicoplast DNA polymerase, Eric Evan Parrott

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The Panicum mosaic virus-like 3' cap-independent translation element: A translation enhancer that functions in mammalian systems, Mariko Sada Peterson

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Specificity of the cocaine aptamer and its application in measurement of cocaine and metabolites in homogeneous samples for forensic analysis, Ashish Sachan

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Investigating higher-order chromatin structure and SAGA cooperativity using existing and modified in vitro chromatin systems, Divya Sinha

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Structural and functional study of SNARE machinery in neurotransmitter release, Shuang Song

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Structure and function of class one non-symbiotic plant hemoglobins, Ryan Thomas Sturms

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Purification and optimization of sequential biosynthetic enzymes for co-localization onto a nanocarrier, Mollie Tiernan

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A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis, Changfu Yao

Theses/Dissertations from 2012

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Characterization of the T4 Mre11/Rad50 complex and investigation of the Mre11 dimeric interface, Dustin William Albrecht

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Understanding Higher Order Heterochromatin Structure And Its Determinants, Abdelhamid Azzaz

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Immunoglobulin motions and antigen binding effects examined by elastic network models, Debkanta Chakraborty

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Mechanistic investigations of class II diterpene cyclases, Jared Criswell

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Deciphering the Details of RNA Aminoglycoside Interactions: From Atomistic Models to Biotechnological Applications, Muslum Ilgu

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Fatty acid changes in soybean (Glycine max) under soybean aphid (Aphis glycines) infestation and their implications on plant defense against insects, Charles Kanobe

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Role of the N-terminus of Recombinant Human Brain Hexokinase in Mitochondrial Binding, Manjit Maskey

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The Arabidopsis CRINKLY4 receptor-like kinase and homologs: Regulation of kinase activity through intra- and intermolecular interactions, Matthew Richard Meyer

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Chemical characterization of hydrocarbons and transcriptome profiling to elucidate pathway(s) of hydrocarbon biosynthesis in maize, pea, Botryococcus braunii and Emiliania huxleyi, Wenmin Qin

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Structural and biochemical characterization of marburgvirus VP35 and its role in immune evasion, Parameshwaran Ramanan

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Allosteric Mechanisms in Recombinant Human Hexokinase Type I, Lu Shen

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Investigating labdane-related diterpenoids biosynthetic network in rice: characterization of cytochromes P450 and short-chain alcohol dehydrogenases/reductase, Yisheng Wu

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Study of Lcn2 in inflammation and characterization of its RNA aptamer, Lijie Zhai

Theses/Dissertations from 2011

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Functional analysis of the JIL-1 histone H3 kinase in Drosophila, Weili Cai

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Fatty acid elongase (FAE) systems: An investigation of genetic redundancy, Alexis Ann Campbell

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Study of the effect of α-Synuclein on SNARE-mediated membrane fusion, Wei Feng

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Isobutene formation from 3-hydroxy-3-methylbutyrate (3-HMB) by the Saccharomyces cerevisiae diphosphomevalonate decarboxylase (ScMDD) and directed enzyme evolution to improve enzyme function, David Gogerty

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RNA structure-mediated regulation of cap-independent transaltion by plant viruses, Jelena Jeremic Kraft

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Protein sequence-structure relationships, Sumudu Pamoda Leelananda

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Concentrations of creatine, creatinine, carnosine, and anserine in bovine longissimus muscle and their correlations with carcass and palatability traits, Qi Liu

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Effects of glucagon, glycerol, and glucagon plus glycerol on gluconeogenesis, lipogenesis, and lipolysis in periparturient Holstein cows, Nimer Mehyar

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Human brain hexokinase: Determinants of mitochondrial binding and mechanism of nucleotide release, Nimer Mehyar

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Single Residue Determinants in the Binding of Recombinant Human Brain Hexokinase to the Mitochondrion, Nidhi Shah

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Fast learning optimized prediction methodology for protein secondary structure prediction, relative solvent accessibility prediction and phosphorylation prediction, Saraswathi Sundararajan

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Studies of the structure and function of Mms6, a bacterial protein that promotes the formation of magnetic nanoparticles, Lijun Wang

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Structure and function of class I diterpene synthase, Ke Zhou

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Engineering Escherichia coli for co-production of acetaldehyde and hydrogen from glucose, Huilin Zhu

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Identification and characterization of the major outer membrane proteins of Haemophilus parasuis for the rational development of a vaccine candidate and diagnostic for Glässer's disease, Mandy Kay Zimmerli

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Mechanistic insights on important biomolecules derived using simple dynamics models from extending the reach of elastic network modeling, Michael Thomas Zimmermann

Theses/Dissertations from 2010

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Variation of carnitine concentrations in Angus beef, Almass A. Abuzaid

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Effects of macronutrient and caloric content of the diet on circulating concentrations of ghrelin and other hormones involved in energy metabolism, Michelle Marie Bohan Brown

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Recycling of vitamin B12 and NAD+ within the Pdu microcompartment of Salmonella enterica, Shouqiang Cheng

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Functional analysis of the extended N-terminus for the Drosophila Raf protein and initial characterization of the Arl1 gene, Jian Ding

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Genetic polymorphisms in bovine ferroportin are associated with beef iron content, Qing Duan

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Genetic, biochemical and physiological studies of acetyl-CoA metabolism via acyl-condensation, Huanan Jin

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Structure and Reactivity of Hexacoordinate Hemoglobins, Smita Kakar

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Interaction between the SAGA complex and chromatin regulates nucleosome acetylation and inducible gene transcription, Shanshan Li

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Functional Study of Transcription Factor MYB305 in Tobacco Flower Development, Guangyu Liu

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Investigation of the molecular mechanism of SNARE-mediated membrane fusion, Bin Lu

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Genetic regulation of bovine milk fatty acid composition: Improving the healthfulness of milk through selection, Rafael Nafikov

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Vitamin D signaling in the bovine immune system, Corwin Drew Nelson

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Plasminogen activator inhibitor 1: mechanisms of its synergistic regulation by growth factors, Xiaoling Song

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Transcriptional defense response of the soybean plant, Glycine max, in reaction to infestation by the soybean aphid, Aphis glycines, Matthew Edward Studham

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P450s in the biosynthesis of diterpenoid phytoalexins in rice, Qiang Wang

Theses/Dissertations from 2009

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Protein structure prediction and conformational transitions, Haitao Cheng

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Biochemical and mutational analysis of coenzyme B12 biosynthesis, Chenguang Fan

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Biotin biosynthetic enzymes and the metabolic control of biotin biosynthesis, Jennifer Ashley Gray

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Regulation, function, and evolution of T2 RNases, Melissa Sue Hillwig

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PduL is an evolutionary distinct phosphotransacylase involved in B12-dependent 1,2-propanediol degradation by Salmonella enterica serovar Typhimurium LT2 and is associated with the propanediol utilization microcompartments, Yu Liu

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Selection and characterization of RNA aptamers that detect a quaternary structure for ribosomal protein S7, Allison Layne Pappas