Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae
Date
2013-01-01
Authors
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Peters, Reuben
Distinguished Professor
Research Projects
Organizational Units
Organizational Unit
Journal Issue
Is Version Of
Versions
Series
Department
Biochemistry, Biophysics and Molecular Biology
Abstract
Miltiradiene (1), is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).
Comments
This is a manuscript of an article published as Zi, Jiachen, and Reuben J. Peters. "Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae." Organic & biomolecular chemistry 11, no. 44 (2013): 7650-7652. doi: 10.1039/C3OB41885E. Posted with permission.
Description
Keywords
Citation
DOI
Copyright
Tue Jan 01 00:00:00 UTC 2013