Nematode effector proteins: an emerging paradigm of parasitism

Mitchum, Melissa; Hussey, Richard; Baum, Thomas; Baum, Thomas; Wang, Xiaohong; Elling, Axel; Wubben, Martin; Davis, Eric

Nematode effector proteins: an emerging paradigm of parasitism

File

2013_Baum_NematodeEffector.pdf (1.44 MB)

Date

2013-09-01

Authors

Mitchum, Melissa

Hussey, Richard

Baum, Thomas

Wang, Xiaohong

Elling, Axel

Wubben, Martin

Davis, Eric

Authors

Person

Baum, Thomas

Distinguished Professor

Organizational Units

Organizational Unit

Plant Pathology and Microbiology

The Department of Plant Pathology and Microbiology and the Department of Entomology officially merged as of September 1, 2022. The new department is known as the Department of Plant Pathology, Entomology, and Microbiology (PPEM). The overall mission of the Department is to benefit society through research, teaching, and extension activities that improve pest management and prevent disease. Collectively, the Department consists of about 100 faculty, staff, and students who are engaged in research, teaching, and extension activities that are central to the mission of the College of Agriculture and Life Sciences. The Department possesses state-of-the-art research and teaching facilities in the Advanced Research and Teaching Building and in Science II. In addition, research and extension activities are performed off-campus at the Field Extension Education Laboratory, the Horticulture Station, the Agriculture Engineering/Agronomy Farm, and several Research and Demonstration Farms located around the state. Furthermore, the Department houses the Plant and Insect Diagnostic Clinic, the Iowa Soybean Research Center, the Insect Zoo, and BugGuide. Several USDA-ARS scientists are also affiliated with the Department.

Department

Plant Pathology and Microbiology

Abstract

Phytonematodes use a stylet and secreted effectors to modify host cells and ingest nutrients to support their growth and development. The molecular function of nematode effectors is currently the subject of intense investigation. In this review, we summarize our current understanding of nematode effectors, with a particular focus on proteinaceous stylet-secreted effectors of sedentary endoparasitic phytonematodes, for which a wealth of information has surfaced in the past 10 yr. We provide an update on the effector repertoires of several of the most economically important genera of phytonematodes and discuss current approaches to dissecting their function. Lastly, we highlight the latest breakthroughs in effector discovery that promise to shed new light on effector diversity and function across the phylum Nematoda.

Comments

This article is published as Mitchum, Melissa G., Richard S. Hussey, Thomas J. Baum, Xiaohong Wang, Axel A. Elling, Martin Wubben, and Eric L. Davis. "Nematode effector proteins: an emerging paradigm of parasitism." New Phytologist 199, no. 4 (2013): 879-894, doi: 10.1111/nph.12323.