Environmentally Responsive Molecular Baskets: Unimolecular Mimics of Both Micelles and Reversed Micelles
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
When four facially amphiphilic cholate derivatives are attached to a tetraaminocalixarene scaffold, the resulting molecule responds to environmental changes by rotation of the cholate units. In polar solvents, the molecule adopts a micellelike conformation with the hydrophilic α-faces of the cholates pointing outward. In nonpolar solvents, it turns inside out, assuming a reversed micellelike conformation with the hydrophobic β-faces pointing outward. Switching between the two conformations is driven by solvophobic interactions and is fully reversible.
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Reprinted (adapted) with permission from Organic Letters (2004): 3187, doi:10.1021/ol048679p. Copyright 2004 American Chemical Society.