On October 25, 1956, a one year old dark roan Shorthorn heifer was admitted to Stange Memorial Clinic at Iowa State College. The animal had been sick most of the summer with difficult respiration. When the heifer was turned out on pasture, her condition declined steadily. She appeared in fair condition upon arrival at the clinic, not showing any extreme emaciation. She was showing dyspnea, polypnea, anorexia, and constipation but did not seem to be extremely depressed. There was a mucous nasal discharge with some sloughing of muzzle epidermis. The skin seemed to lack normal pliability. In addition, the animal showed considerable mouth breathing. The respiratory rate was 52 per minute, the pulse rate 120 per minute, and the temperature 102.8 degrees. Upon exertion or exercise, the animal tired very easily and showed increased respiratory difficulty. Auscultation of the lungs revealed increased vesicular sounds over the entire lung on both the left and right sides.