Document Type

Article

Publication Version

Published Version

Publication Date

5-2011

Journal or Book Title

Bioinformatics and Biology Insights

Volume

5

First Page

99

Last Page

113

DOI

10.4137/BBI.S6930

Abstract

The developing retina is an excellent model to study cellular fate determination and differentiation in the context of a complex tissue. Over the last decade, many basic principles and key genes that underlie these processes have been experimentally identified. In this review, we construct network models to summarize known gene interactions that underlie determination and fundamentally affect differentiation of each retinal cell type. These networks can act as a scaffold to assemble subsequent discoveries. In addition, these summary networks provide a rational segue to systems biology approaches necessary to understand the many events leading to appropriate cellular determination and differentiation in the developing retina and other complex tissues.

Comments

This article is from Bioinformatics and Biology Insights 5 (2011): 99, doi:10.4137/BBI.S6930. Posted with permission.

Rights

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Copyright Owner

Xia Zhang, et al.

Language

en

File Format

application/pdf

Share

COinS