Campus Units

Ecology, Evolution and Organismal Biology

Document Type

Article

Publication Version

Published Version

Publication Date

6-2007

Journal or Book Title

Aging Cell

Volume

6

Issue

3

First Page

395

Last Page

404

DOI

10.1111/j.1474-9726.2007.00287.x

Abstract

We test the ‘free radical theory of aging’ using six species of colubrid snakes (numerous, widely distributed, non-venomous snakes of the family Colubridae) that exhibit long (> 15 years) or short (< 10 years) lifespans. Because the ‘rate of living theory’ predicts metabolic rates to be correlated with rates of aging and oxidative damage results from normal metabolic processes we sought to answer whether physiological parameters and locomotor performance (which is a good predictor of survival in juvenile snakes) mirrored the evolution of lifespans in these colubrid snakes. We measured whole animal metabolic rate (oxygen consumption ), locomotor performance, cellular metabolic rate (mitochondrial oxygen consumption), and oxidative stress potential (hydrogen peroxide production by mitochondria). Longer-lived colubrid snakes have greater locomotor performance and reduced hydrogen peroxide production than short-lived species, while whole animal metabolic rates and mitochondrial efficiency did not differ with lifespan. We present the first measures testing the ‘free radical theory of aging’ using reptilian species as model organisms. Using reptiles with different lifespans as model organisms should provide greater insight into mechanisms of aging.

Comments

This article is from Aging Cell 6 (2007): 395, doi: 10.1111/j.1474-9726.2007.00287.x. Posted with permission.

Rights

This article is made available under a Creative Commons Attribution Non-Commercial License. For more information please visit http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%292045-8827/homepage/open_access_license_and_copyright.htm

Copyright Owner

The Authors

Language

en

File Format

application/pdf

Share

COinS