Document Type

Article

Publication Date

2009

Journal or Book Title

Vector-Borne and Zoonotic Diseases

Volume

10

Issue

2

First Page

207

Last Page

209

DOI

10.1089/vbz.2008.0158

Abstract

Fox squirrels (Sciurus niger) (five of eight) were infected with West Nile virus (WNV) when challenged by the oral route with 102.3 or 103.4 plaque forming units (PFU). The mean maximum serum WNV titer of infected fox squirrels was 105.1 PFU/mL and ranged from 104.6 to 105.6 PFU/mL. These levels of viremia are infectious for several mosquito vectors of WNV. This virus was also isolated from swabs of the oral and rectal cavities, and urine swabs between day 5 and 9 postexposure (p.e.) in amounts as high as 102.0, 102.8, and 102 PFU, respectively. WNV RNA was detected in salivary gland and/or kidney tissue of three squirrels between day 65 and 72 p.e. in the presence of WNV neutralizing antibody, suggesting that long-term persistent infection occurs in fox squirrels. These observations justify further studies to determine if nonarthropod transmission and long-term persistent infection occur naturally in fox squirrels and contribute to trans-seasonal maintenance of WNV.

Comments

This article is from Vector-Borne and Zoonotic Diseases 10 (2009): 207, 10.1089/vbz.2008.0158. Posted with permission.

Rights

This is a copy of an article published in the Vector-Borne and Zoonotic Diseases © 2009 [copyright Mary Ann Liebert, Inc.]; Vector-Borne and Zoonotic Diseases is available online at: http://online.liebertpub.com

Copyright Owner

Mary Ann Liebert, Inc.

Language

en

File Format

application/pdf

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