Campus Units

Biomedical Sciences, Entomology

Document Type

Book Chapter

Publication Version

Published Version

Publication Date

9-25-2013

Journal or Book Title

Pest Management with Natural Products

Volume

1141

Issue

7

First Page

97

Last Page

110

DOI

10.1021/bk-2013-1141.ch007

Abstract

Monoterpenoids are found in essential oils from numerous plant families. Octopamine is a biogenic monoamine found within various invertebrates, including insects. Octopamine exerts its physiological effects through the activation of G-protein-coupled receptors (GPCRs). GPCRs are an under-utilized receptor target in the agrochemical industry. Here we report the expression of an octopamine receptor from the brain of the American cockroach (Periplaneta americana) inSaccharomyces cerevisiae, creating a ligand-independent histidine-auxotrophic assay. The majority of monoterpenoids acted as an inverse agonist in this system. Three QSAR models show that electronic properties are most important for monoterpenoid interaction with this octopamine receptor in this yeast assay.

Comments

Reprinted (adapted) with permission from Pest Management with Natural Products, 1141(7); 97-110. Doi: 10.1021/bk-2013-1141.ch007. 2013 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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