Campus Units

Entomology

Document Type

Article

Publication Version

Published Version

Publication Date

7-1990

Journal or Book Title

Environmental Health Perspectives

Volume

87

First Page

255

Last Page

262

Abstract

The mechanisms and sites of action of organochlorine (DDT-types and chlorinated alicyclics) and synthetic pyrethroid insecticides are presented with discussion of symptoms, physiological effects, and selectivity. The structural requirements for toxicity are assessed, and structure-activity relationships are considered for each subclass. Lipophilicity is important for all the groups because it facilitates delivery of these neurotoxicants to the site of action in the nerve. Steric factors including molecular volume, shape, and isomeric configuration greatly influence toxicity. Electronic parameters also have been demonstrated to affect biological activity in some of the groups of insecticides, e.g., Hammett's sigma and Taft's sigma * as indicators of electronegativity. New synthetic pyrethroids continue to be developed, with varied structures and different physicochemical and biological properties.

Comments

Reproduced with permission from Environmental Health Perspectives, July 1990 87; 255-262. Posted with permission.

Copyright Owner

Environmental Health Perspectives

Language

en

File Format

application/pdf