Campus Units

Entomology, Biomedical Sciences

Document Type

Article

Publication Version

Published Version

Publication Date

2-1-2017

Journal or Book Title

Chemico-Biological Interactions

Volume

263

First Page

1

Last Page

6

DOI

10.1016/j.cbi.2016.12.009

Abstract

An outbreak of the southern cattle tick, Rhipicephalus (Boophilus) microplus, (Canestrini), in the United States would have devastating consequences on the cattle industry. Tick populations have developed resistance to current acaricides, highlighting the need to identify new biochemical targets along with new chemistry. Furthermore, acaricide resistance could further hamper control of tick populations during an outbreak. Botanically-based compounds may provide a safe alternative for efficacious control of the southern cattle tick. We have developed a heterologous expression system that stably expresses the cattle tick's tyramine receptor with a G-protein chimera, producing a system that is amenable to high-throughput screening. Screening an in-house terpenoid library, at two screening concentrations (10 μM and 100 μM), has identified four terpenoids (piperonyl alcohol, 1,4-cineole, carvacrol and isoeugenol) that we believe are positive modulators of the southern cattle tick's tyramine receptor.

Comments

This article is from Chemico-Biological Interactions, Volume 263, 1 February 2017, Pages 1–6, doi:10.1016/j.cbi.2016.12.009.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf