Degree Type

Dissertation

Date of Award

2010

Degree Name

Doctor of Philosophy

Department

Chemical and Biological Engineering

First Advisor

Rodney O. Fox

Abstract

A model study has been conducted for Flash Nanoprecipitation(FNP)) - a novel approach to produce functional nanoparticles. A mixing study has been conducted in a custom-designed microscale multi-inlet vortex reactor (MIVR) and a scalar mixing model was validated against experimental data. A microPIV experiment was conducted to further validate the turbulent model. A population balance equation (PBE) has been proposed to model the FNP process. It was furthermore, integrated into a computational fluid dynamics (CFD) simulation of to yield conditions comparable to the real experimental settings. In coping with the complicated aggregation model in the CFD code, a new numerical approach, conditional quadrature method of moments (CQMOM), has been proposed, which is capable of solving the multivariate system efficiently and accurately. It is shown that the FNP process is highly influenced by mixing effects in the microreactor and thus coupling CFD with the kinetics model is essential in obtaining valid comparisons with experiments.

Copyright Owner

Janine Chungyin Cheng

Language

en

Date Available

2012-04-30

File Format

application/pdf

File Size

192 pages

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