Date of Award
Master of Science
Veterinary Diagnostic and Production Animal Medicine
Porcine circovirus type 2 (PCV2) is the causative agent of a variety of disease manifestations in swine that has a major impact on the swine industry. This thesis contains an introduction, a literature review, two scientific studies, and a general conclusions section. The objectives of the studies were to determine the transmission of PCV2 and the efficacy of two vaccines, an inactivated chimeric vaccine and a live-attenuated chimeric vaccine, in either pregnant sows or growing pigs in a challenge model. The results from this thesis indicate that vaccination of both sows and growing pigs with the inactivated-chimeric vaccine induced higher levels of PCV2-specific antibodies sooner than vaccination with the live-attenuated chimeric vaccine. Vaccination of both sows and growing pigs led to a reduction in viremia regardless of vaccine type used, however. In addition, these studies showed that vaccination of sows does not prevent in-utero spread of PCV2, and closure of a pig herd for 140 days could provide stabilization of herd immunity.
Grabosch, Michelle, "Studies on transmission of porcine circovirus type 2 (PCV2)" (2011). Graduate Theses and Dissertations. 12333.