In November 2004, Asian soybean rust was confirmed in the continental United States. Iowa farmers were concerned that this disease would infect locally grown soybeans; therefore, many purchased fungicides to ensure their availability if needed. BASF Corporation agronomists have reported that applications of Headline fungicide improve general soybean plant health and ultimately improve yields. Local farmers wanted to know if an application of Headline fungicide would improve plant health and yields in our area. This study was started to investigate yield responses of soybeans to Headline fungicide.