Document Type

Article

Publication Date

10-1993

Journal or Book Title

Journal of Agricultural and Food Chemistry

Volume

41

Issue

10

First Page

1649

Last Page

1654

DOI

10.1021/jf00034a025

Abstract

Male F344/ N rats were fed corn, nixtamalized corn, Fusarium proli feratum- fermented (FP) corn to provide 50 mg/kg fumonisin B1 (FB1), or nixtamalized FP corn (NFP), with and without supplemented nutrients. Nixtamalization of FP corn almost completely hydrolyzed FB1 and produced 7-10 mg/kg hydrolyzed fumonisin (HFB1). Relative liver weight was significantly increased in nutrient-supplemented rats fed FP or NFP corn. Plasma cholesterol increased in rats fed FP or NFP corn. Plasma glutamate­ pyruvate transaminase was elevated in allrats fed FP corn and in nutrient-supplemented rats fed NFP corn. All rats fed FP corn and nutrient-supplemented rats fed NFP corn exhibited hepatocellular adenomas, whereas unsupplemented rats fed NFP corn had few adenomas. HFB1 and other uncharacterized F. proli feratum mycotoxins produced by nixtamalization were less toxic than were toxicants, including FB1, present in FP corn. Improvement in nutritional status due to nixtamalization stimulated NFP corn toxicity.

Comments

Reprinted with permission from Journal of Agricultural and Food Chemistry. 41(10):1649-1654. doi: 10.1021/jf00034a025. Copyright 1993 American Chemical Society.

Rights

One-time permission is granted only for the use specified in your request. No additional uses are granted (such as derivative works or other editions).

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Share

COinS