Campus Units

Genetics, Development and Cell Biology

Document Type

Conference Proceeding

Conference

Sixth Annual MCBIOS Conference

Publication Version

Published Version

Publication Date

2009

Journal or Book Title

BMC Bioinformatics

Volume

10

Issue

Supplement 11

First Page

S18

DOI

10.1186/1471-2105-10-S11-S18

Conference Title

Transformational Bioinformatics: Delivering Value from Genomes

Conference Date

February 20-21, 2009

City

Starkville, MS, USA

Abstract

Motivation

The increasingly large amount of free, online biological text makes automatic interaction extraction correspondingly attractive. Machine learning is one strategy that works by uncovering and using useful properties that are implicit in the text. However these properties are usually not reported in the literature explicitly. By investigating specific properties of biological text passages in this paper, we aim to facilitate an alternative strategy, the use of text empirics, to support mining of biomedical texts for biomolecular interactions. We report on our application of this approach, and also report some empirical findings about an important class of passages. These may be useful to others who may also wish to use the empirical properties we describe.

Results

We manually analyzed syntactic and semantic properties of sentences likely to describe interactions between biomolecules. The resulting empirical data were used to design an algorithm for the PathBinder system to extract biomolecular interactions from texts. PathBinder searches PubMed for sentences describing interactions between two given biomolecules. PathBinder then uses probabilistic methods to combine evidence from multiple relevant sentences in PubMed to assess the relative likelihood of interaction between two arbitrary biomolecules. A biomolecular interaction network was constructed based on those likelihoods.

Conclusion

The text empirics approach used here supports computationally friendly, performance competitive, automatic extraction of biomolecular interactions from texts.

Comments

This is a proceeding from Sixth Annual MCBIOS Conference. Transformational Bioinformatics: Delivering Value from Genomes 10 (2009): S18, doi: 10.1186/1471-2105-10-S11-S18. Posted with permission.

Rights

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright Owner

Zhang et al

Language

en

File Format

application/pdf

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