Campus Units

Genetics, Development and Cell Biology

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

10-2007

Journal or Book Title

Science

Volume

318

Issue

5848

First Page

245

Last Page

250

DOI

10.1126/science.1143609

Abstract

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

Comments

This manuscript is published as Merchant, Sabeeha S., Simon E. Prochnik, Olivier Vallon, Elizabeth H. Harris, Steven J. Karpowicz, George B. Witman, Astrid Terry et al. "The Chlamydomonas genome reveals the evolution of key animal and plant functions." Science 318, no. 5848 (2007): 245-250. 10.1126/science.1143609. Posted with permission.

Copyright Owner

American Association for the Advancement of Science

Language

en

File Format

application/pdf

Published Version

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