Campus Units

Genetics, Development and Cell Biology

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2011

Journal or Book Title

Cancer Cell

Volume

20

Issue

2

First Page

260

Last Page

275

DOI

10.1016/j.ccr.2011.07.005

Abstract

It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been debated for over a century. Here, we report that human and mouse retinoblastomas have molecular, cellular, and neurochemical features of multiple cell classes, principally amacrine/horizontal interneurons, retinal progenitor cells, and photoreceptors. Importantly, single-cell gene expression array analysis showed that these multiple cell type-specific developmental programs are coexpressed in individual retinoblastoma cells, which creates a progenitor/neuronal hybrid cell. Furthermore, neurotransmitter receptors, transporters, and biosynthetic enzymes are expressed in human retinoblastoma, and targeted disruption of these pathways reduces retinoblastoma growth in vivo and in vitro.

Comments

This is a manuscript of an article from Cancer Cell 20 (2011): 260, doi: 10.1016/j.ccr.2011.07.005. Posted with permission.

Copyright Owner

Elsevier Inc.

Language

en

File Format

application/pdf

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