This paper presents a novel modeling methodology that integrates the near building environmental conditions (or microclimate), whole-building design, and occupant behavior. Accurate predictions of the future building operating conditions lead to designs that serve the building’s purpose – to support occupants’ tasks. This study bridges the gap between human factors and architecture to include physical, cognitive, and organizational systems into building information modeling using future typical meteorological year climate data, canyon air temperature microclimate model, and a whole-building energy simulation to investigate the impact of future microclimate conditions on a “typical” single-occupant office. Additionally, to capture the effects of building occupant decision-making and adaptive behaviors, an agent-based model is proposed. Model inputs are task-based which aim to produce a more robust model to investigate a variety of human-building control interactions to ensure high building performance and occupant comfort and satisfaction.