Iowa State University Veterinarian Records, RS 22/6/0/9, University Archives, Special Collections Department, Iowa State University, http://www.add.lib.iastate.edu/spcl/arch/rgrp/22-6-0-9.html
In 1902 the term anaphylaxis was coined to describe a condition observed in animals and in 1904 Theobald Smith made the important observation that guinea pigs could be easily sensitized and thus provided a laboratory animal for experimental use. In 1910 Barger & Dale isolated histamine from ergot and Dale was led to believe that the pharmacological effects of histamine in animals resembled those seen in anaphylactic shock.
Austin, James A.
"Two Recent Developments Veterinary Therapeutics,"
Iowa State University Veterinarian: Vol. 12
, Article 5.
Available at: http://lib.dr.iastate.edu/iowastate_veterinarian/vol12/iss2/5