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Iowa State University Veterinarian

Collection

Iowa State University Veterinarian Records, RS 22/6/0/9, University Archives, Special Collections Department, Iowa State University, http://www.add.lib.iastate.edu/spcl/arch/rgrp/22-6-0-9.html

Call Number

SF601 V65

Document Type

Article

Abstract

In 1902 the term anaphylaxis was coined to describe a condition observed in animals and in 1904 Theobald Smith made the important observation that guinea pigs could be easily sensitized and thus provided a laboratory animal for experimental use. In 1910 Barger & Dale isolated histamine from ergot and Dale was led to believe that the pharmacological effects of histamine in animals resembled those seen in anaphylactic shock.

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