Campus Units

Mechanical Engineering, Biomedical Sciences, Ames Laboratory

Document Type

Article

Publication Date

4-2016

Journal or Book Title

Materials

Volume

9

Issue

5

First Page

321-1

Last Page

321-13

DOI

10.3390/ma9050321

Abstract

Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.

Comments

This is an article from Materials 9 (2016): 321, doi: 10.3390/ma9050321. Posted with permission.

Rights

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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