Campus Units

Mechanical Engineering

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

11-17-2017

Journal or Book Title

Macromolecular Bioscience

First Page

1700279

DOI

10.1002/mabi.201700279

Abstract

Microfibers have received much attention due to their promise for creating flexible and highly relevant tissue models for use in biomedical applications such as 3D cell culture, tissue modeling, and clinical treatments. A generated tissue or implanted material should mimic the natural microenvironment in terms of structural and mechanical properties as well as cell adhesion, differentiation, and growth rate. Therefore, the mechanical and biological properties of the fibers are of importance. This paper briefly introduces common fiber fabrication approaches, provides examples of polymers used in biomedical applications, and then reviews the methods applied to modify the mechanical and biological properties of fibers fabricated using different approaches for creating a highly controlled microenvironment for cell culturing. It is shown that microfibers are a highly tunable and versatile tool with great promise for creating 3D cell cultures with specific properties.

Comments

This is a manuscript of an article published as M. C. McNamara, F. Sharifi, A. H. Wrede, D. F. Kimlinger, D.-G. Thomas, J. B. Vander Wiel, Y. Chen, R. Montazami, N. N. Hashemi, Macromol. Biosci. 2017, 1700279. doi: 10.1002/mabi.201700279. Posted with permission.

Copyright Owner

Wiley-VCH Verlag

Language

en

File Format

application/pdf

Available for download on Saturday, November 17, 2018

Published Version

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