Vaccines for counteracting inhibition of neutrophil degranulation by pathogenic cellular microorganisms comprise one or more purines conjugated to antigenic carriers. The purines include adenine and/or guanine in the form of a base, nucleoside, or nucleotide. The vaccines can be used with cattle to increase resistance to infections by Brucella abortus (brucellosis) and/or Haemophilus somnus (thromboembolic meningoencephalitis) and related symptomatic complex.
ISURF Reference Number
Iowa State University Research Foundation, Inc.,
Roth, James A.; Canning, Peter C.; and Chiang, Yu-Wei, "Vaccines for counteracting inhibition of neutrophil degranulation" (1987). Iowa State University Patents. 235.