Chemistry, Physics and Astronomy, Bioinformatics and Computational Biology
Journal or Book Title
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps.
© 2014 Bolla et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Bolla et al.
Reddy Bolla, Jani; Su, Chih-Chia; Do, Sylvia V.; Radhakrishnan, Pattathil; Kumar, Nitin; Long, Feng; Chou, Tsung-Han; Delmar, Jared A.; Lei, Hsiang-Ting; Rajashankar, Kanagalaghatta R.; Shafer, William M.; and Yu, Edward, "Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump" (2014). Physics and Astronomy Publications. 168.