Document Type

Article

Publication Date

4-2013

Journal or Book Title

Proceedings of the National Academy of Sciences of the United States of America

Volume

110

Issue

23

First Page

9309

Last Page

9313

DOI

10.1073/pnas.1218472110

Abstract

During the past decade, a large body of research has shown that memory traces can become labile upon retrieval and must be restabilized. Critically, interrupting this reconsolidation process can abolish a previously stable memory. Although a large number of studies have demonstrated this reconsolidation associated amnesia in nonhuman animals, the evidence for its occurrence in humans is far less compelling, especially with regard to declarative memory. In fact, reactivating a declarative memory often makes it more robust and less susceptible to subsequent disruptions. Here we show that existing declarative memories can be selectively impaired by using a noninvasive retrieval–relearning technique. In six experiments, we show that this reconsolidation-associated amnesia can be achieved 48 h after formation of the original memory, but only if relearning occurred soon after retrieval. Furthermore, the amnesic effect persists for at least 24 h, cannot be attributed solely to source confusion and is attainable only when relearning targets specific existing memories for impairment. These results demonstrate that human declarative memory can be selectively rewritten during reconsolidation.

Comments

This is a manuscript of an article from Proceedings of the National Academy of Sciences 110 (2013): 9309, doi:10.1073/pnas.1218472110. Posted with permission.

Copyright Owner

Chan, et al.

Language

en

File Format

application/pdf

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