Salmonella sp. are a leading cause of gastro-intestinal disease in humans with tens of millions of human cases worldwide every year. Pork is an important food vehicle of Salmonellosis, resulting in fever, abdominal cramps, diarrhea, vomiting, and occasionally death. Reduction of Salmonella in the feed-to-food chain is key to reduce the number of human Salmonellosis cases. Furthermore, it has frequently been demonstrated that the use of antimicrobial agents in food animals favors the development of resistance among foodborne pathogens like Salmonella spp. Therefore, there is an urgent need for new antibacterial strategies to reduce Salmonellosis, since antimicrobial resistance is on the rise.