The gene-for-gene hypothesis has been found applicable to several host-parasite interactions in which the parasite is a fungus. It has most satisfactorily explained interactions involving cereal rust and powdery mildew diseases in which cases the pathogens are obligate parasites and the genes of both the parasites and hosts may be manipulated in genetic tests. Generally, the gene-for-gene hypothesis has not been applied to host-virus systems because virulence genes in viruses cannot be manipulated by hybridization.
Roane, Curtis W.; Tolin, Sue A.; and Buss, Glenn R.
"Research Notes : United States : Application of the gene-for-gene hypothesis to soybean-soybean mosaic virus interactions,"
Soybean Genetics Newsletter: Vol. 13
, Article 31.
Available at: http://lib.dr.iastate.edu/soybeangenetics/vol13/iss1/31