We have developed methods to identify genetic differences at the VCAM1 gene in pigs. We identified significant variability in Chinese and American breeds, with three different forms of this gene and five of the six possible resulting genotypes seen in Duroc and Landrace breeds. This variability was used to map the VCAM1 gene to pig chromosome 4, a chromosome with important quantitative trait loci. We also used our methods to physically map VCAM1 to the end of the long arm of chromosome 4, confirming the genetic linkage assignment.
Iowa State University
Tuggle, Christopher K.; Yu, Tun-Ping; Sun, Hsiao-Fang; Wang, Lizhen; Rothschild, Max F.; and Yerle, M., "Genetic and Physical Mapping of the pig Vascular Cell Adhesion Molecule 1 (VCAM1) gene to pig chromosome 4" (1997). Swine Research Report, 1996. 23.