Campus Units

Zoology

Document Type

Article

Publication Version

Published Version

Publication Date

1995

Journal or Book Title

Nucleic Acids Research

Volume

23

Issue

4

First Page

696

Last Page

700

DOI

10.1093/nar/23.4.696

Abstract

G-DNA is a polymorphic family of quadruple helical nucleic acid structures containing guanine tetrad motifs [G-quartets; Willlamson, J. R., Raghuraman.M.K. and CechJ.R. (1989) Cell 59, 871–880; Williamson. J. R. (1993) Proc. Natl. Acad. Scl . USA 90, 3124–3124]. Guanine rich oligonucleotides that are self-complimentary, as found in many telomeric G-strand repeat sequences, form G-DNA in the presence of mono-valent and/or divalent metal cations. In this report we use the atomic force microscope (AFM) to explore the structural characteristics of long, linear polymers formed by the telomeric oligonucleotide d(GGGG TTGGGG) in the presence of specific metal cations. In the AFM these polymers, termed G-wires, appear as filaments whose height and length are determined by the metal ions present during the self-assembly process. The highly ordered, controllable serf-assembly of G-wires could provide a basis for developing advanced blomaterials.

Comments

This article is from Nucleic Acids Research 23 (1995): 696, doi: 10.1093/nar/23.4.696. Posted with permission.

Copyright Owner

Oxford University Press

Language

en

File Format

application/pdf

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