Campus Units

Zoology

Document Type

Article

Publication Version

Published Version

Publication Date

1992

Journal or Book Title

Nucleic Acids Research

Volume

20

Issue

3

First Page

445

Last Page

447

DOI

10.1093/nar/20.3.445

Abstract

The atomic force microscope (AFM) was used to image supercooled plasmid DMA deposited on a mica surface in either a hydrated or desiccated state. Hydrated plasmid was precisely cut by the scanning tip at a location determined by the instrument operator. Small pieces of DNA (100–150 nm in length) were excised and deposited adjacent to the dissected plasmid, demonstrating that it is possible to remove and manipulate genomic DNA fragments, unresolvable by light microscopy, from defined chromosomal locations by AFM.

Comments

This article is from Nucleic Acids Research 20 (1992): 445, doi: 10.1093/nar/20.3.445. Posted with permission.

Copyright Owner

Oxford University Press

Language

en

File Format

application/pdf

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