Uncertainty exists with corn (Zea mays L.) N management due to year-to-year variation in crop N need, soil N supply, and N loss from leaching, volatilization, and denitrification. Active-optical reflectance sensing (AORS) has proven effective in some fields for generating N fertilizer recommendations that improve N use efficiency, but locally derived (e.g., within a US state) AORS algorithms have not been tested simultaneously across a broad region. The objective of this research was to evaluate locally developed AORS algorithms across the US Midwest Corn Belt region for making in-season corn N recommendations. Forty-nine N response trials were conducted across eight states and three growing seasons. Reflectance measurements were collected and sidedress N rates (45–270 kg N ha^–1 on 45 kg ha^–1increments) applied at approximately V9 corn development stage. Nitrogen recommendation rates from AORS algorithms were compared with the end-of-season calculated economic optimal N rate (EONR). No algorithm was within 34 kg N ha^–1 of EONR > 50% of the time. Average recommendations differed from EONR 81 to 147 kg N ha^–1 with no N applied at planting and 74 to 118 kg N ha^–1 with 45 kg of N ha^–1 at planting, indicating algorithms performed worse with no N applied at planting. With some algorithms, utilizing red edge instead of the red reflectance improved N recommendations. Results demonstrate AORS algorithms developed under a particular set of conditions may not, at least without modification, perform very well in regions outside those within which they were developed.