Campus Units

Agronomy, Genetics, Development and Cell Biology, Statistics, Bioinformatics and Computational Biology, Genetics, Plant Biology

Document Type

Article

Publication Version

Published Version

Publication Date

11-20-2009

Journal or Book Title

PLoS Genetics

Volume

5

Issue

11

First Page

e1000734

DOI

10.1371/journal.pgen.1000734

Abstract

Following the domestication of maize over the past ∼10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation, including copy number variation (CNV) and presence/absence variation (PAV), which are thought to contribute to the extraordinary phenotypic diversity and plasticity of this important crop, have not been elucidated. Whole-genome, array-based, comparative genomic hybridization (CGH) revealed a level of structural diversity between the inbred lines B73 and Mo17 that is unprecedented among higher eukaryotes. A detailed analysis of altered segments of DNA conservatively estimates that there are several hundred CNV sequences among the two genotypes, as well as several thousand PAV sequences that are present in B73 but not Mo17. Haplotype-specific PAVs contain hundreds of single-copy, expressed genes that may contribute to heterosis and to the extraordinary phenotypic diversity of this important crop.

Comments

This article is from PLoS Genet 5(11): e1000734. doi:10.1371/journal.pgen.1000734. Posted with permission.

Rights

© 2009 Springer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Copyright Owner

2009

Language

en

File Format

application/pdf

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