Campus Units

Agronomy, Genetics, Development and Cell Biology, Plant Biology

Document Type

Article

Publication Version

Published Version

Publication Date

2-2016

Journal or Book Title

Plant Biotechnology Journal

Volume

14

Issue

2

First Page

510

Last Page

518

DOI

10.1111/pbi.12444

Abstract

Genome editing with engineered nucleases (GEEN) represents a highly specific and efficient tool for crop improvement with the potential to rapidly generate useful novel phenotypes/traits. Genome editing techniques initiate specifically targeted double strand breaks facilitating DNA-repair pathways that lead to base additions or deletions by non-homologous end joining as well as targeted gene replacements or transgene insertions involving homology-directed repair mechanisms. Many of these techniques and the ancillary processes they employ generate phenotypic variation that is indistinguishable from that obtained through natural means or conventional mutagenesis; and therefore, they do not readily fit current definitions of genetically engineered or genetically modified used within most regulatory regimes. Addressing ambiguities regarding the regulatory status of genome editing techniques is critical to their application for development of economically useful crop traits. Continued regulatory focus on the process used, rather than the nature of the novel phenotype developed, results in confusion on the part of regulators, product developers, and the public alike and creates uncertainty as of the use of genome engineering tools for crop improvement.

Comments

This article is from Plant Biotechnology Journal 14 (2015): 510–518, doi:10.1111/pbi.12444. Posted with permission.

Rights

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Copyright Owner

The authors

Language

en

File Format

application/pdf

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